The near 40-year quest for an AIDS vaccine received a hopeful boost Saturday when scientists announced that a trial drug triggered an immune response in humans and shielded monkeys from infection.
Shown to be safe in humans, the candidate vaccine has now advanced to the next phase of the pre-approval trial process, and will be tested in 2,600 women in southern Africa to see whether it prevents HIV infection.
While the results so far have been encouraging, the research team and outside experts warn there are no guarantees it will actually work in the next trial phase dubbed HVTN705 or “Imbokodo” — the isiZulu word for “rock”.
“Although these data are promising, we need to remain cautious,” study leader Dan Barouch, a Harvard Medical School professor, told AFP.
Just because it protected two-thirds of monkeys in a lab trial doesn’t mean the drug will protect humans, “and thus we need to await the results of the… study before we know whether or not this vaccine will protect humans against HIV infection,” he said.